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A Guide to the Properties of Kratom’s Alkaloids

A Guide to the Properties of Kratom’s Alkaloids

  • By - Guillermo Rojo
  • 26 April, 2023

Alkaloids and Why They're Important

Kratom has become increasingly popular recently, with people turning to it for its many benefits. One of the primary reasons behind its popularity is its alkaloids. Alkaloids are chemical compounds occurring naturally in plants, significantly impacting the product's properties. This article will examine the important alkaloids and explore their effects on the human body.

Understanding The Alkaloids

Kratom is a tropical tree species that grows natively in Southeast Asia, primarily in Indonesia, Thailand, and Malaysia. The leaves of these trees contain many alkaloids that have been known to offer many beneficial effects. Ranging from relaxation, energy boost, mood enhancement, and euphoria, depending on the dose, color, and strain.

Kratom, known as Mitragyna speciosa, belongs to the same family as the coffee plant, and its leaves have been used for centuries for their therapeutic and medicinal properties. Traditionally, its leaves were chewed or brewed into tea to relieve pain and boost energy during long work hours. Nowadays, it is processed into tea, capsules, or powder to make it more convenient for users to consume.

The Importance of Alkaloids

The alkaloids are mainly responsible for the plant's psychoactive effects. There are more than 40 alkaloids in Kratom, but the five primary alkaloids are Mitragynine, 7-Hydroxymitragynine, Speciogynine, Paynantheine, and Speciociliatine. Each alkaloid has a unique effect on the human body, with Mitragynine and 7-Hydroxymitragynine being the most abundant and potent.

It works by binding to the opioid receptors in the brain, which reduces pain perception and provides a boost of energy. 7-Hydroxymitragynine, on the other hand, is known for its potent analgesic effects and is considered to be 13 times more potent than morphine. It also has sedative properties and can induce a feeling of relaxation and calmness.

Speciogynine, Paynantheine, and Speciociliatine are present in smaller amounts but still play a significant role in the overall effects of your experience. Speciogynine is known for its muscle relaxant and anti-inflammatory properties, while Paynantheine has mild analgesic effects and can help to reduce stress and anxiety. Speciociliatine is believed to have similar effects to Mitragynine and may also have anti-inflammatory properties.

Overall, the alkaloids work together to provide a range of beneficial effects, depending on the dosage and strain used. While Kratom has been used for centuries for its medicinal properties, it is important to note that the FDA does not approve it for any medical use, and it should be used cautiously.

The Major Alkaloids in Kratom

Kratom, known as Mitragyna speciosa, is a tropical evergreen tree found in Southeast Asia. The tree leaves contain several active compounds, known as alkaloids, responsible for their medicinal and recreational effects.


Mitragynine is the most abundant alkaloid in Kratom, making up almost two-thirds of the total alkaloid content. It’s responsible for Kratom’s pain-relieving effects and acts on the same receptors as opioids. However, unlike opioids, Mitragynine doesn’t cause breathing depression which is very interesting to the medical community.

When Mitragynine interacts with the receptors in the brain, it initiates the release of endorphins, which are the body's natural painkillers. This process helps to support pain and discomfort, making Mitragynine a natural, popular alternative to prescription painkillers.


7-Hydroxymitragynine is the most potent alkaloid present, making up less than 2% of the total alkaloid content. It binds to the same receptors as Mitragynine and is responsible for profound sedative effects.

Users report feeling relaxed and calm after consuming their suggested serving, and this is due to the presence of 7-Hydroxymitragynine. The alkaloid has been found to have a higher affinity for the receptors than Mitragynine, making it more potent and effective at supporting sedation.


Speciogynine is another alkaloid that binds to the same receptors as Mitragynine, but it’s not as potent. It’s believed to contribute to mood-enhancing effects and may help users to overcome anxiety.

Speciogynine has been found to have a relaxing effect on the mind and body. It helps to promote a sense of calm and well-being, making Kratom an ideal natural remedy for stress and anxiety.


Paynantheine is a less potent alkaloid that’s believed to contribute to Kratom’s pain-relieving properties. It was found to help alleviate inflammation and reduce pain in animal models.

Paynantheine has been found to have anti-inflammatory properties, which makes it an effective natural support for pain and discomfort. It helps to fight inflammation when brewed as an anti-inflammatory tea.


Speciociliatine is the least abundant alkaloid, making up less than 1% of the total alkaloid content. It’s believed to play a minor role in Kratom’s overall effects and has been found to be a weak stimulant.

Speciociliatine has been found to help boost energy levels and improve focus and concentration. It’s a milder alkaloid than the others, but it still contributes to Kratom’s overall effects.

In conclusion, Kratom contains several active alkaloids that work together to provide a range of medicinal and recreational effects. While Mitragynine and 7-Hydroxymitragynine are the most potent alkaloids, Speciogynine, Paynantheine, and Speciociliatine also play important roles in Kratom’s overall effects.

Effects of Kratom Alkaloids on the Human Body

Kratom, a tropical tree native to Southeast Asia, has long been used for its medicinal properties. The leaves of the Kratom plant contain a variety of alkaloids, which are responsible for its therapeutic effects on the human body. In this article, we’ll explore the different ways in which Kratom’s alkaloids affect the body.


The Relaxation effects of Kratom’s alkaloids are one of the primary reasons why people turn to Kratom. Mitragynine and 7-Hydroxymitragynine bind to the same receptors that opioids do but are less powerful in their effects.

One study found that Kratom’s alkaloids effectively reduced pain levels in mice. The researchers concluded that Kratom could be a potential alternative to traditional pain medications.

Mood Enhancement

Kratom’s alkaloids, particularly Speciogynine, are believed to play a significant role in regulating mood. They interact with the brain’s receptors to reduce anxiety, alleviate depression, and increase feelings of well-being and contentment.

Many Kratom users report feeling a sense of euphoria after taking Kratom. This is thought to be due to the release of endorphins in the brain, which are responsible for feelings of pleasure and happiness.

Energy Boost

Kratom’s alkaloids, especially Mitragynine and Speciociliatine, have been found to boost energy levels and increase focus. They’re thought to achieve this by increasing blood flow to the brain and activating receptors that enhance cognitive function.

In Southeast Asia, laborers have used Kratom as a natural energy booster. Students have also used it to help them focus and study for long periods. White strains have higher amounts of these alkaloids and make good kratom products for these purposes.

Relaxation and Sedation

Kratom’s 7-Hydroxymitragynine is responsible for its sedative effects. When it binds to the receptors in the brain, it initiates relaxation, which, in turn, leads to sedation. This effect can help those who suffer from insomnia and other sleep disorders.

Kratom has also been used as a natural muscle relaxant. It can help to alleviate tension headaches, muscle spasms, and even menstrual cramps.

In conclusion, Kratom’s alkaloids have various therapeutic effects on the human body. From pain relief to mood enhancement, Kratom has been used for centuries as a natural supplement for various ailments. As with any natural remedy, it’s important to use Kratom responsibly and under the guidance of a healthcare professional.


Kratom’s alkaloids offer many benefits, making it a popular choice for people seeking a natural remedy for various ailments. While the alkaloids in Kratom have been studied extensively, much more research is needed to determine their full potential. Nevertheless, many users continue to report positive experiences and recommend Kratom for its many beneficial effects.

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